When the Los Angeles Chargers match up with the Denver Broncos at 4:05 p.m. ET on Sunday, Sept. 21, our projection model predicts the Chargers will take home the win. Our model also projects the spead, point total, and final score, which you can check out below.
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Chargers vs. Broncos Game Info and TV Channel
- When: Sunday, September 21, 2025 at 4:05 p.m. ET
- Where: SoFi Stadium in Inglewood, California
- TV: CBS
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- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Listen to the game on ALT 98.7
Chargers vs. Broncos Odds and Betting Info
- Spread favorite: Chargers (-3)
- Moneyline: Chargers (-154), Broncos (+130)
- Total: 45.5 points
Chargers vs. Broncos Prediction
- Pick ATS: Broncos (+3)
- Pick OU: Under (45.5)
Prediction:
Chargers 22 - Broncos 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chargers vs. Broncos Betting Insights
- The Chargers have a record of 2-0-0 against the spread this season.
- The Broncos are winless against the spread this season (0-2-0).
- Los Angeles has won their only game this season when playing as at least 3-point favorites.
- Chargers games have hit the over once this season.
- Broncos games have gone over the point total once this season.
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