Matthew Stafford Week 1 Preview vs. the 49ers

Los Angeles Rams v Los Angeles Chargers

Photo: Harry How / Getty Images Sport / Getty Images

Los Angeles Rams quarterback Matthew Stafford has a good matchup in Week 1 (Thursday at 8:35 p.m. ET), playing the San Francisco 49ers. The 49ers gave up the eighth-most passing yards last season, 232.4 per game.

Stafford passed for 4,707 yards last year (276.9 per game), completing 65% of his passes (388-for-597), with 46 TDs and eight INTs.

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Stafford vs. the 49ers

  • Stafford vs the 49ers (since 2021): 6 GP / 305.7 PASS YPG / 16 PASS TD
  • Last year, San Francisco allowed four quarterbacks to register over 300 passing yards in a game.
  • Last year, the 49ers allowed 15 QBs to throw at least one TD pass in a game.
  • Against San Francisco last season, 10 players threw for at least two touchdowns in a game.
  • Versus the 49ers last year, just three players threw for at least three touchdowns in a game.
  • Stafford will face the NFL's 25th-ranked pass defense a year ago (232.4 yards allowed per game).
  • The 49ers gave up 29 TDs in the passing game last year (1.7 per game) to rank 21st among NFL defenses.

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Stafford Passing Insights

  • Stafford hit the over on passing yards prop bets in 10 of 15 opportunities last season (66.7%).
  • The Rams ran 56.3% passing plays and 43.7% rushing plays last season. They ranked first in the NFL in scoring.
  • Stafford was sixth in the league with 7.9 yards per pass attempt last year (4,707 total yards passing).
  • Stafford had a passing touchdown in all 17 games last season, with multiple passing TDs in 15 of them.

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Stafford's Last Season Performance

Opponent Date Week Passing Stats Rushing Stats
vs. Texans 9/7/2025 Week 1 21-for-29 / 245 YDS / 1 TD / 0 INTs 4 ATT / -2 YDS / 0 TDs
vs. Titans 9/14/2025 Week 2 23-for-33 / 298 YDS / 2 TDs / 1 INT 2 ATT / -6 YDS / 0 TDs
vs. Eagles 9/21/2025 Week 3 19-for-33 / 196 YDS / 2 TDs / 1 INT 0 ATT / 0 YDS / 0 TDs
vs. Colts 9/28/2025 Week 4 29-for-41 / 375 YDS / 3 TDs / 0 INTs 4 ATT / 4 YDS / 0 TDs
vs. 49ers 10/2/2025 Week 5 30-for-47 / 389 YDS / 3 TDs / 0 INTs 1 ATT / 0 YDS / 0 TDs
vs. Ravens 10/12/2025 Week 6 17-for-26 / 181 YDS / 1 TD / 0 INTs 4 ATT / 1 YDS / 0 TDs
vs. Jaguars 10/19/2025 Week 7 21-for-33 / 182 YDS / 5 TDs / 0 INTs 2 ATT / 1 YDS / 0 TDs
vs. Saints 11/2/2025 Week 9 24-for-32 / 281 YDS / 4 TDs / 0 INTs 4 ATT / -4 YDS / 0 TDs
vs. 49ers 11/9/2025 Week 10 24-for-36 / 280 YDS / 4 TDs / 0 INTs 3 ATT / -3 YDS / 0 TDs
vs. Seahawks 11/16/2025 Week 11 15-for-28 / 130 YDS / 2 TDs / 0 INTs 0 ATT / 0 YDS / 0 TDs
vs. Buccaneers 11/23/2025 Week 12 25-for-35 / 273 YDS / 3 TDs / 0 INTs 0 ATT / 0 YDS / 0 TDs
vs. Panthers 11/30/2025 Week 13 18-for-28 / 243 YDS / 2 TDs / 2 INTs 1 ATT / -1 YDS / 0 TDs
vs. Cardinals 12/7/2025 Week 14 22-for-31 / 281 YDS / 3 TDs / 0 INTs 0 ATT / 0 YDS / 0 TDs
vs. Lions 12/14/2025 Week 15 24-for-38 / 368 YDS / 2 TDs / 1 INT 1 ATT / 2 YDS / 0 TDs
vs. Seahawks 12/18/2025 Week 16 29-for-49 / 457 YDS / 3 TDs / 0 INTs 2 ATT / 6 YDS / 0 TDs
vs. Falcons 12/29/2025 Week 17 22-for-38 / 269 YDS / 2 TDs / 3 INTs 0 ATT / 0 YDS / 0 TDs
vs. Cardinals 1/4/2026 Week 18 25-for-40 / 259 YDS / 4 TDs / 0 INTs 1 ATT / 3 YDS / 0 TDs
vs. Panthers 1/10/2026 Wild Card 24-for-42 / 304 YDS / 3 TDs / 1 INT 2 ATT / 0 YDS / 0 TDs
vs. Bears 1/18/2026 Divisional 20-for-42 / 258 YDS / 0 TDs / 0 INTs 1 ATT / -1 YDS / 0 TDs
vs. Seahawks 1/25/2026 Conf. Championship 22-for-35 / 374 YDS / 3 TDs / 0 INTs 2 ATT / 16 YDS / 0 TDs

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